Re: 請問Efexor XR - 精神疾病

※ 引述《phiby (超可愛貓)》之銘言：
: ※ 引述《chihlingchen (.........)》之銘言：
: : 我吃3顆 中午1顆 晚上2顆
: : 平常不覺得吃這個藥對自己的情緒有什麼改善
: : 前幾天晚上去看電影 結果忘了晚上該吃的2顆
: : 隔天開始就一直昏昏沉沉想睡覺 一直狂睡
: : 什麼事都不想做 真糟糕 也不想吃東西
: : 一開始吃時食慾很差 體重直直落
: : 習慣這個藥之後就好了點
: : 但是那天忘了吃之後 身體變的怪怪的
: : 什麼都不想 不想吃 不想動 又變瘦了
: : 我實在不想再瘦下去 3字頭讓人覺得瘦得噁心><
: : ---------------------------------------------
: : 初次po文 今天才發現除了prozac之外 還有這個版쨊: 我大約兩週前有碰到一個吞服28天Efexor劑量要自殺的病人
: 當天在急診做完簡單的處理後就收到我們病房來了
: 至於over dose 的 sign 幾乎沒有文獻記載
: 當天早上入院 下午2PM病人開始 sizure, 而且意識欠清
: 眼神無打對焦 呈驚獗狀, 而且當天病人 sizure 兩次
: 尿也尿不出來 所以on上導尿管.....
: 我po這篇的目的是 大家在用藥上要小心, 醫生是專業的
: 想減藥可以跟醫生商量 不要自己減藥或調藥
If you take too many Efexor-XR
capsules you may:
* feel sleepy;
* have an increased heart rate;
* have a seizure (fits);
* have breathing difficulties;
* become unconscious;
* have dilated pupils.

以上出自http://health.ninemsn.com.au/MEDICATIONS/

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OVERDOSAGE
Human Experience

There were 14 reports of acute overdose with Effexor
(venlafaxine hydrochloride), either alone
or in combination with other drugs and/or alcohol, among the
patients included in the premarketing evaluation.
The majority of the reports involved ingestions in which the
total dose of Effexor taken was estimated to be no more
than several-fold higher than the usual therapeutic
dose.

The 3 patients who took the highest doses were estimated
to have ingested approximately 6.75 g, 2.75 g, and 2.5 g.
The resultant peak plasma levels of venlafaxine for the
latter 2 patients were 6.24 and 2.35 μg/mL, respectively,
and the peak plasma levels of O-desmethylvenlafaxine
were 3.37 and 1.30 μg/mL, respectively.

Plasma venlafaxine levels were not obtained for the
patient who ingested 6.75 g of venlafaxine.
All 14 patients recovered without sequelae.
Most patients reported no symptoms.
Among the remaining patients, somnolence was the most commonly
reported symptom. The patient who ingested 2.75 g of
venlafaxine was observed to have 2 generalized convulsions
and a prolongation of QTc to 500 msec, compared with 405 msec
at baseline. Mild sinus tachycardia was reported in 2 of the other patients.


In postmarketing experience, overdose with venlafaxine has
occurred predominantly in combination with alcohol and/or
other drugs. Electrocardiogram changes (eg, prolongation of
QT interval, bundle branch block, QRS prolongation),
sinus and ventricular tachycardia, bradycardia, hypotension,
altered level of consciousness (ranging from somnolence to coma),
rhabdomyolysis, seizures, vertigo, and death have been reported.

以上出自惠氏藥廠網頁
http://www.wyeth.com/products/all.asp

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