請問何種情形不適合服用愛瑞沙？？？ - 肺癌

※ 引述《prehn (dicey and paltry)》之銘言：
: ※ 引述《winibaby (winibaby的冒險)》之銘言：
: : 不好意思 我想請問一下
: : 因為他聽說可以治療 肺癌
: : 希望有人可以解惑謝謝
: : 而且吃他的副作用有可能有間質性肺炎
: : 是什麼情形呢？？
: 只能用在非肺小細胞癌囉...
: 最好有EGFR MUTATION, EXON 16,17,18 吧...


還要在後面壹點 exon 18, 19, 20, 21


卓參 詳見 paper from CGMH VGH-TPE

Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor
Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients
with Non–Small Cell Lung Cancer
Clin. Cancer Res. 2005 11: 3750-3757.

High Frequency of Epidermal Growth Factor Receptor Mutations
with Complex Patterns
in Non–Small Cell Lung Cancers Related to
Gefitinib Responsiveness in Taiwan

Clin. Cancer Res. 2004 10: 8195-8203.


sorry 我打字 慢 to put it in English

exon 18, 19, 20, 21 are the tyrosin kinase domain untill exon 21


Pao W, Miller V, Zakowski M, Doherty J, Politi K, et al.
(2004) EGF receptor gene mutations are common in lung cancers from “
never smokers” and are associated with sensitivity of tumors to
gefitinib and erlotinib. Proc Natl Acad Sci U S A 101: 13306–13311


: 效果一到二成.....
: 但我有看過效果不錯的...吃二個多月. 腫瘤全消...
: 但他的EGFR MUTATION 好像有 PRESENT
: TARCEVA 也是新一代的囉...


irresa seems to be ALMOST withdrawal or LIMITED in its indication as FDA
announced (IRRESA withdraw its application in European market)

http://www.fda.gov/cder/drug/infopage/iressa/iressaQ&A2005.htm
Date created: June 17, 2005

(this is due to the fact that the end point of trial IDEAL or what ?(ISEL)
showed no advantage, comparing irresa and placebo)

TARCEVA now turn to "the only" FDA approved EGFR-TKI

Are TARCEVA related to anti-angiogenesis ?

: EGFR-TKI
: 知道就這些啦....
: m34789

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